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Antidepressants Can Interfere With Pain Relief Of Common Opioids:
spoonie-living:
Folks, this study came out
very
recently (Feb 2019), so your doctor may not yet know about it.
The article does a decent job of summarizing the research, but here’s the extra-short version:
Affected: Prodrug opioids (such as Vicodin and Norco)
Not affected: Direct-acting opioids (such as morphine and oxycodone)
They hypothesize that this has to do with the way the SSRIs inhibit certain enzymes in the liver that process the prodrug opioids into something the body can use.
Now, this study was specifically about SSRIs (the most common class of anti-depressant) used with prodrug or direct-acting opioids—so there was no research on how other antidepressants could impact prodrug opioid effectiveness. If they’re correct about the inhibition of that enzyme, though, certain non-SSRIs could have the same or similar impact on prodrug opioids.
Wondering if your non-SSRI antidepressant has potential to lessen your pain relief? This chart has a column for inhibitors of the enzyme in question (there are some other interesting inhibitors on there, too!).
The full study can be found here, and appears to be free to view.
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Antidepressants Can Interfere With Pain Relief Of Common Opioids:
spoonie-living:
Folks, this study came out
very
recently (Feb 2019), so your doctor may not yet know about it.
The article does a decent job of summarizing the research, but here’s the extra-short version:
Affected: Prodrug opioids (such as Vicodin and Norco)
Not affected: Direct-acting opioids (such as morphine and oxycodone)
They hypothesize that this has to do with the way the SSRIs inhibit certain enzymes in the liver that process the prodrug opioids into something the body can use.
Now, this study was specifically about SSRIs (the most common class of anti-depressant) used with prodrug or direct-acting opioids—so there was no research on how other antidepressants could impact prodrug opioid effectiveness. If they’re correct about the inhibition of that enzyme, though, certain non-SSRIs could have the same or similar impact on prodrug opioids.
Wondering if your non-SSRI antidepressant has potential to lessen your pain relief? This chart has a column for inhibitors of the enzyme in question (there are some other interesting inhibitors on there, too!).
The full study can be found here, and appears to be free to view.
(Your picture was not posted)
